Deckert T, Poulsen J E
Diabetologia. 1981 Sep;21(3):178-83. doi: 10.1007/BF00252651.
Twenty-one young onset Type 1 (insulin dependent) diabetics who developed severe diabetic nephropathy after 14.5 +/- 3.3 years (mean +/- SD) and 21 age and sex matched Type 1 diabetics without evidence of nephropathy after more than 32 years of disease were compared with particular reference to body build, insulin requirements, stability of diabetes, heart rate and blood pressure before the development of nephropathy. Attempts were made to evaluate the quality of metabolic control during the first 20 years of diabetes from more than 1,600 out-patient measurements of blood and urinary glucose in each group. The renal tubular reabsorption capacity for glucose was calculated in both groups. No differences between the two groups were found for any of the parameters examined, except that the frequency of ketoacidosis was higher in the patients who developed nephropathy. It is concluded that many Type 1 diabetics seem to be protected against the deleterious effect of diabetes on the kidney. The nature of the protecting factors is unknown.
21例青年发病的1型（胰岛素依赖型）糖尿病患者在14.5±3.3年（均值±标准差）后发生了严重的糖尿病肾病，将其与21例年龄和性别相匹配、病程超过32年且无肾病证据的1型糖尿病患者进行比较，特别关注肾病发生前的体型、胰岛素需求量、糖尿病稳定性、心率和血压。通过对每组1600多次门诊血、尿葡萄糖测量，试图评估糖尿病最初20年期间的代谢控制质量。计算了两组的肾小管葡萄糖重吸收能力。除了发生肾病的患者中酮症酸中毒的频率较高外，在检查的任何参数中两组均未发现差异。得出的结论是，许多1型糖尿病患者似乎受到保护，免受糖尿病对肾脏的有害影响。保护因素的性质尚不清楚。
