Nillius S J, Bergh T, Lundberg P O, Stahle J, Wide L
Fertil Steril. 1978 Dec;30(6):710-2. doi: 10.1016/s0015-0282(16)43702-7.
A nulliparous woman with 12 years of amenorrhea, galactorrhea, and hyperprolactinemia and radiologic evidence of a pituitary macroadenoma was treated with large doses of bromocriptine. During treatment the greatly increased prolactin levels normalized and ovulatory menstrual cycles were regained after 48 weeks of treatment. A transsphenoidal surgical exploration of the pituitary fossa was performed after 27 months of treatment. The findings at surgery suggested that regression of the pituitary adenoma had occurred during the prolonged treatment with bromocriptine. After discontinuation of the therapy, the patient continued to ovulate and subsequently conceived.
一名未生育女性，闭经12年，有溢乳和高催乳素血症，影像学检查显示垂体大腺瘤，接受了大剂量溴隐亭治疗。治疗期间，大幅升高的催乳素水平恢复正常，治疗48周后恢复了有排卵的月经周期。治疗27个月后对垂体窝进行了经蝶窦手术探查。手术结果表明，在长期溴隐亭治疗期间垂体腺瘤已发生退缩。停止治疗后，患者继续排卵并随后受孕。
