Kovalev O A, Larin V L, Severovostokova V I, Sheremetevskaia S K, Khomutova I A
Fiziol Zh SSSR Im I M Sechenova. 1978 Nov;64(11):1613-8.
Unanesthetized rats put in the hermetic chamber breathed with a gas mixture containing 10.5% of oxygen in nitrogen during 30 and 60 min (moderate hypoxia), and 3.5% of oxygen in nitrogen for 30 min (severe hypoxia). The circulating blood volume increased in moderate hypoxia but was rather reduced in severe hypoxia. Mobilization of blood from the liver occurred in moderate hypoxia after 30 min, becoming less obvious after 60 min or in severe hypoxia. Redistribution of blood in the myocardium, skeletal muscles of the head and neck occurred in moderate hypoxia. Severe hypoxia led to depression of the regional circulating blod redistribution and the signs of pathological accumulation of the blood in the liver, small intestine, colon and testicles.
将未麻醉的大鼠置于密闭舱内,使其在含10.5%氧气的氮气混合气体中呼吸30分钟和60分钟(中度缺氧),以及在含3.5%氧气的氮气中呼吸30分钟(重度缺氧)。在中度缺氧时循环血量增加,但在重度缺氧时则显著减少。在中度缺氧30分钟后肝脏出现血液动员,60分钟后或在重度缺氧时这种现象不太明显。在中度缺氧时心肌、头部和颈部骨骼肌会出现血液重新分布。重度缺氧导致局部循环血液重新分布受到抑制,以及肝脏、小肠、结肠和睾丸出现血液病理性蓄积的迹象。