Ohlson D L, Spicer L J, Davis S L
J Anim Sci. 1981 Jun;52(6):1350-9. doi: 10.2527/jas1981.5261350x.
An experiment was conducted to determine whether prolactin (PRL) is involved in the maintenance of reproductive tissue weights and body growth in yearling rams. Suppression of circulating PRL was achieved by active antibody production against bovine PRL. Free plasma PRL concentrations in immunized rams were decreased (P less than .05) by 73% after 3 months of treatment and 91% after 10 months of treatment in relation to concentrations in control rams. Average daily gain and final body weight were lower (P less than .05) for rams with suppressed circulating PRL (.042 kg/day and 67.0 kg for treatment rams and .060 kg/day and 72.7 kg for control rams). Although testes weights were 32% lower for the treated rams, antibody treatment did not affect (P greater than .05) the weights of the testes or accessory sex glands. No treatment effect was noted on plasma luteinizing hormone (LH), growth hormone (GH) or thyrotropin (TSH). Seasonal differences were observed in some variables of LH, GH and TSH secretion. Mean baseline LH for all animals was higher (P less than .01) in December than in March, June or September. Overall and baseline concentration of GH and TSh were highest (P less than .01) in December. These data suggest that (1) PRL is involved in body growth of the yearling ram, and (2) PRL may have a role in the maintenance of reproductive tissue weights in the yearling ram.
进行了一项实验，以确定催乳素（PRL）是否参与一岁公羊生殖组织重量的维持和身体生长。通过产生针对牛PRL的活性抗体来抑制循环中的PRL。与对照公羊相比，免疫公羊的游离血浆PRL浓度在治疗3个月后降低了73%（P<0.05），在治疗10个月后降低了91%。循环PRL受到抑制的公羊的平均日增重和最终体重较低（P<0.05）（治疗公羊为0.042千克/天和67.0千克，对照公羊为0.060千克/天和72.7千克）。虽然治疗公羊的睾丸重量低32%，但抗体治疗对睾丸或附属性腺的重量没有影响（P>0.05）。未观察到对血浆促黄体生成素（LH）、生长激素（GH）或促甲状腺激素（TSH）的治疗效果。在LH、GH和TSH分泌的一些变量中观察到季节性差异。所有动物的平均基础LH在12月高于3月、6月或9月（P<0.01）。GH和TSH的总体和基础浓度在12月最高（P<0.01）。这些数据表明：（1）PRL参与一岁公羊的身体生长；（2）PRL可能在一岁公羊生殖组织重量的维持中起作用。
