Golden D B, Langois J, Valentine M D, Kagey-Sobotka A, Lichtenstein L M
JAMA. 1981 Nov 27;246(21):2460-3.
Whole-body extracts (WBEs) remain in widespread use for therapy of insect sting anaphylaxis two years after the approval of Hymenoptera venoms. We have reviewed our experience with WBEs in our patient population. Of 250 patients who received WBE, 115 had subsequent stings. Systemic allergic reactions occurred in 65% large local reactions in 23%, and no reaction in 12%. There was no consistent change in the severity of systemic reactions during WBE treatment. Systemic reaction occurred less commonly in younger persons or after at least two years of WBE treatment. We conclude that WBE is not effective for the prevention of allergic insect sting reactions. The natural history of the disease may account for its apparent efficacy in young people or those having prolonged WBE therapy. Venom immunotherapy is safe and rapidly effective and is the only protective treatment recommended.
在膜翅目毒液获批两年后，全身提取物（WBEs）仍广泛用于治疗昆虫叮咬过敏反应。我们回顾了在我们患者群体中使用WBEs的经验。在接受WBE治疗的250名患者中，115人随后被叮咬。全身过敏反应发生率为65%，局部严重反应发生率为23%，无反应发生率为12%。在WBE治疗期间，全身反应的严重程度没有持续变化。全身反应在年轻人中或至少经过两年WBE治疗后较少发生。我们得出结论，WBE对预防过敏性昆虫叮咬反应无效。该疾病的自然病程可能解释了其在年轻人或接受长期WBE治疗者中看似有效的原因。毒液免疫疗法安全且起效迅速，是唯一推荐的预防性治疗方法。
