Slutsky A S, Brown R, Lehr J, Rossing T, Drazen J M
Med Instrum. 1981 Jul-Aug;15(4):229-33.
Adequate pulmonary ventilation can be achieved in experimental animals and in humans using tidal volumes on the order of the anatomic dead space volume applied at very high ventilatory frequencies (3-30 Hz). Classical mechanism of gas exchange cannot account for these paradoxical observations, but theories based on the concept of augmented diffusion may provide an adequate explanation for this phenomenon. Even though the exact mechanisms accounting for gas exchange are not well understood, a number of successful ventilators have been designed and tested based on the concept of small volume/high frequency ventilation. The differences among these various ventilators are compared and contrasted and possible clinical uses of the technique are discussed.
在实验动物和人类中，使用与解剖无效腔容积相当的潮气量，并以非常高的通气频率（3 - 30赫兹）进行通气，可以实现充分的肺通气。传统的气体交换机制无法解释这些矛盾的观察结果，但基于增强扩散概念的理论可能为这一现象提供充分的解释。尽管气体交换的确切机制尚未完全明了，但基于小容积/高频通气概念，已经设计并测试了许多成功的呼吸机。本文比较并对比了这些不同呼吸机之间的差异，并讨论了该技术可能的临床应用。
