Lee R B, Neglia W, Park R C
Obstet Gynecol. 1981 Nov;58(5):584-9.
Forty-one cases of invasive carcinoma of the cervix associated with pregnancy that were treated at the Walter Reed Army Medical Center from January 1961 through April 1979 were reviewed. Postpartum patients were included in the study if the diagnosis of cancer was made within 6 months of delivery. Three cases of clinical stage IA disease treated by Wertheim-Taussig hysterectomy had a 5-year survival rate of 100%. There were 22 cases of stage IB disease with a 5-year actuarial survival rate of 90%. Four patients with stage IB were treated by radiotherapy, 17 by Wertheim-Taussig hysterectomy, and 1 by a combination of pelvic irradiation, cesium application, and simple extrafascial total abdominal hysterectomy and bilateral salpingo-oophorectomy for a barrel-shaped cervix. Twelve cases of stage II disease treated by radiotherapy had a 5-year actuarial survival rate of 24%. There were no survivors in 2 cases of stages III and IV disease. The 5-year actuarial survival rate of patients with stage I carcinoma of the cervix associated with pregnancy is not statistically different from that of nonpregnant patients, regardless of the method of treatment.
回顾了1961年1月至1979年4月在沃尔特·里德陆军医疗中心接受治疗的41例妊娠合并子宫颈浸润癌病例。如果在分娩后6个月内确诊癌症，则产后患者纳入研究。3例经韦特海姆-陶西格子宫切除术治疗的临床IA期疾病患者的5年生存率为100%。有22例IB期疾病患者，5年精算生存率为90%。4例IB期患者接受放射治疗，17例接受韦特海姆-陶西格子宫切除术，1例因桶状宫颈接受盆腔照射、铯敷贴、单纯筋膜外全腹子宫切除术和双侧输卵管卵巢切除术联合治疗。12例经放射治疗的II期疾病患者的5年精算生存率为24%。2例III期和IV期疾病患者无幸存者。妊娠合并子宫颈I期癌患者的5年精算生存率与非妊娠患者相比，无论治疗方法如何，在统计学上无差异。
