6-取代胸腺嘧啶核苷的合成。
Synthesis of 6-substituted thymine nucleosides.
作者信息
von Janta-Lipinski M, Langen P
出版信息
Nucleic Acids Symp Ser. 1981(9):41-4.
PMID:7301598
Abstract
The preparation of several N(1)-glycosyl derivatives of 6-fluorothymine is described. The displacement of the fluorine atom at the C-6-position of the heterocyclic component lead to a series of new 6-substituted 5-methyl-pyrimidine-2,4-dione-nucleosides. Some of these new compounds show significant virostatic activity against influenza A virus strains.
摘要
描述了几种6-氟胸腺嘧啶的N(1)-糖基衍生物的制备方法。杂环组分C-6位上氟原子的取代产生了一系列新的6-取代的5-甲基嘧啶-2,4-二酮核苷。这些新化合物中的一些对甲型流感病毒株显示出显著的抑制病毒活性。
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