Breeden G C, Turner E C, Beane W L, Miller R W, Pickens L C
Poult Sci. 1981 Mar;60(3):556-62. doi: 10.3382/ps.0600556.
Field trials were conducted in 1974 and 1975 using an encapsulated formulation of methoprene (AltosidTM) applied as a feed additive at rates of 7.5 and 10.0 ppm (AI in feed) to control Musca domestica L. in poultry houses. Only limited inhibition of house fly emergence was obtained. In addition, the percentage of house fly emergence in each trial gradually increased as the season progressed. Comparison bioassays were conducted at the end of the 1975 season between field-pressured strains and lab-reared susceptible strains. Results from the field trials and comparison bioassays indicated that the causes of the poor inhibition were an existing cross-resistance to methoprene followed by an induction of resistance resulting from the continuous exposure to methoprene.
1974年和1975年进行了田间试验，使用烯虫酯（AltosidTM）的胶囊制剂作为饲料添加剂，以7.5和10.0 ppm（饲料中的有效成分）的剂量来控制禽舍中的家蝇（Musca domestica L.）。仅获得了对家蝇羽化的有限抑制。此外，在每个试验中，随着季节的推进，家蝇羽化的百分比逐渐增加。1975年季节结束时，对田间压力菌株和实验室饲养的敏感菌株进行了比较生物测定。田间试验和比较生物测定的结果表明，抑制效果不佳的原因是对烯虫酯已存在交叉抗性，随后是由于持续接触烯虫酯而诱导产生的抗性。
