Schultz P, Mistry S P
Poult Sci. 1981 Mar;60(3):653-8. doi: 10.3382/ps.0600653.
The effect of fatty acids beta-hydroxybutyrate, ethanol, and different pyruvate/lactate ratios on gluconeogenesis in isolated chicken hepatocytes was investigated. Glucogenesis was significantly affected by a change in the oxidation-reduction (pyruvate/lactate) ratio, and this effect was greater than could be accounted for by the additive effects of these substrates. Substituting lactate with nongluconeogenic substrates, such as beta-hydroxybutyrate or ethanol, increased the formation of glucose by 80 and 200%, respectively, demonstrating the beneficial effect of the increased reducing equivalents in the hepatocytes. Oleic acid per se had no effect but when added complexed with albumin, it had a negative effect on gluconeogenesis.
研究了脂肪酸β-羟基丁酸、乙醇以及不同丙酮酸/乳酸比例对分离的鸡肝细胞糖异生的影响。氧化还原（丙酮酸/乳酸）比例的变化对糖异生有显著影响，且这种影响大于这些底物的加和效应所能解释的程度。用非糖异生底物如β-羟基丁酸或乙醇替代乳酸，分别使葡萄糖生成增加了80%和200%，这表明肝细胞中还原当量增加具有有益作用。油酸本身无影响，但与白蛋白复合添加时，对糖异生有负面影响。
