Baker J L, Chandler M L, LeVier R R
Plast Reconstr Surg. 1981 Dec;68(6):905-12. doi: 10.1097/00006534-198112000-00010.
Capsular tissue obtained from a series of 16 patients with silicone mammary implants was exposed in vitro to smooth-muscle stimulants and relaxants. Capsule relaxation was produced in 75 percent of the patients. The most active antagonists were papaverine and veratrine. Capsule contracture was produced in 69 percent of the patients. The most active agonists were histamine and epinephrine. Myofibroblasts were identified in several capsules. These data support the hypothesis that the myofibroblasts is a probable cause of capsular contracture.
从16例硅胶乳房植入患者身上获取的包膜组织在体外暴露于平滑肌兴奋剂和松弛剂。75%的患者出现包膜松弛。最有效的拮抗剂是罂粟碱和藜芦碱。69%的患者出现包膜挛缩。最有效的激动剂是组胺和肾上腺素。在几个包膜中发现了肌成纤维细胞。这些数据支持肌成纤维细胞可能是包膜挛缩原因的假说。
