Michaud P, Gaches J, Foncin J F
Rev Electroencephalogr Neurophysiol Clin. 1981 Jul-Sep;10(3):259-69. doi: 10.1016/s0370-4475(80)80008-6.
Frontal isocortex biopsy or operative specimens exhibited senile plaques in 25 patients aged 40 to 73 years, association with Alzheimer's "neurofibrillary degeneration" in 20 of them. These patients were followed up for up to 14 years. 3 patients died 1 to 3 months after operation. 16 patients evolved into confirmed dementia, 12 of them most probably of the Alzheimer type. 6 patients recovered fully, and their subsequent evolution appears incompatible with a diagnosis of Alzheimer's dementia (follow-up period of 3 to 14 years). Retrospective evaluation of EEG data showed a good predictive value of previously described EEG changes, as indicative of later confirmation of alzheimer's dementia.
额叶皮质活检或手术标本显示，25例年龄在40至73岁的患者存在老年斑，其中20例伴有阿尔茨海默病的“神经原纤维变性”。这些患者接受了长达14年的随访。3例患者术后1至3个月死亡。16例患者发展为确诊痴呆，其中12例很可能为阿尔茨海默病类型。6例患者完全康复，其后续病情发展似乎与阿尔茨海默病痴呆的诊断不符（随访期为3至14年）。对脑电图数据的回顾性评估显示，先前描述的脑电图变化具有良好的预测价值，可指示阿尔茨海默病痴呆的后期确诊。
