Kurtz D, Krieger J, Kowalski J, Hoff E, Mangin P
Rev Electroencephalogr Neurophysiol Clin. 1980 Oct-Dec;10(4):366-75. doi: 10.1016/s0370-4475(80)80034-7.
The authors suggest the hypothesis that the obesity often associated with sleep apnea syndromes is related to changes in HG secretion. Indeed, as HG secretion is sleep related any disturbances due to apnea during may alter the GH secretion. In order to test their hypothesis the authors studied, during the course of 24-hour polygraphic recordings, the levels of HG, blood glucose and free fatty acids, in 16 subjects, 14 of whom were obese and 9 of whom had the sleep apnea syndrome. The results obtained confirmed the relationship between the number of apnea and the stability of sleep. They also demonstrated a relationship between GH secretion and both the stability of sleep and obesity. These results, therefore, suggest that apnea plays a role in obesity development.
作者提出了一个假设，即常与睡眠呼吸暂停综合征相关的肥胖与生长激素（HG）分泌的变化有关。事实上，由于HG分泌与睡眠相关，呼吸暂停期间的任何干扰都可能改变生长激素（GH）的分泌。为了验证他们的假设，作者在24小时多导睡眠记录过程中，研究了16名受试者的HG、血糖和游离脂肪酸水平，其中14人肥胖，9人患有睡眠呼吸暂停综合征。获得的结果证实了呼吸暂停次数与睡眠稳定性之间的关系。他们还证明了生长激素（GH）分泌与睡眠稳定性和肥胖之间的关系。因此，这些结果表明呼吸暂停在肥胖发展中起作用。
