药物代谢改变对兔氯仿诱导心律失常的影响。
Effects of alterations in drug metabolism on chloroform-induced cardiac arrhythmias in rabbits.
作者信息
Carlson G P
出版信息
Res Commun Chem Pathol Pharmacol. 1981 Aug;33(2):349-52.
PMID:7302382
Abstract
Control rabbits or those treated with phenobarbital to induce drug metabolism or SKF 525A or Lilly 18947 to inhibit were exposed by inhalation to 10,500 ppm chloroform for one hour. Phenobarbital treatment decreased blood levels only prior to reaching equilibrium and did not alter the response to epinephrine-induced cardiac arrhythmias. The inhibitors, despite causing higher blood levels of chloroform, did not alter its cardiotoxicity.
摘要
对照兔或用苯巴比妥诱导药物代谢处理的兔，或用SKF 525A或礼来18947抑制处理的兔，通过吸入暴露于10500 ppm氯仿中1小时。苯巴比妥处理仅在达到平衡之前降低了血药浓度，且未改变对肾上腺素诱导的心律失常的反应。这些抑制剂尽管导致氯仿血药浓度升高，但并未改变其心脏毒性。
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