三种胆汁酸结合聚合物对大鼠体内由¹⁴C-醋酸钠合成¹⁴C-胆固醇的影响。
Effect of three bile acid binding polymers on the biosynthesis of 14C-cholesterol from 14C-sodium acetate in the rat.
作者信息
Gilfillan J L, Huff J W
出版信息
Res Commun Chem Pathol Pharmacol. 1981 Aug;33(2):373-6.
PMID:7302387
Abstract
The relative activity of three bile acid binding polymers in increasing cholesterol biosynthesis in the rat from 14C-acetate was determined by measuring blood levels of 14C-cholesterol after intraperitoneally administered 14C-acetate. CAT-FLOC and 3,3-ionene were 4-5 times more active than cholestyramine in this study which correlated well with the results of hypocholesteremic testing in dogs.
摘要
通过测量腹腔注射14C-乙酸盐后大鼠血液中14C-胆固醇的水平，测定了三种胆汁酸结合聚合物在增加大鼠从14C-乙酸盐合成胆固醇方面的相对活性。在本研究中，CAT-FLOC和3,3-紫罗烯的活性比消胆胺高4-5倍，这与犬类降胆固醇测试结果密切相关。
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