性激素对大鼠血小板对二磷酸腺苷敏感性的影响。

The influence of sex hormones on rat platelet sensitivity to adenosine-diphosphate.

作者信息

Orchard M A, Botting J H

出版信息

Thromb Haemost. 1981 Aug 28;46(2):496-9.

Abstract

The sensitivity of rat platelets to the aggregating agent adenosine-diphosphate (ADP) was studied. Platelets form male and female rats demonstrated comparable sensitivity. Neither ovariectomy nor castration altered platelet sensitivity to ADP. However platelets form mock-operated female, but not mock-operated male rats were less sensitive. Administration of physiological doses of 17 beta-oestradiol to ovariectomised rats reduced platelet sensitivity. Administration of 17 beta-oestradiol to mock operated female rats increased platelet sensitivity to ADP. The results suggest that physiological amounts of oestrogen induce a loss of platelet sensitivity following surgery or stress, whereas higher concentrations of oestrogens increase platelet sensitivity.

摘要

研究了大鼠血小板对聚集剂二磷酸腺苷（ADP）的敏感性。雄性和雌性大鼠的血小板表现出相当的敏感性。卵巢切除术和阉割术均未改变血小板对ADP的敏感性。然而，假手术雌性大鼠而非假手术雄性大鼠的血小板敏感性较低。给去卵巢大鼠注射生理剂量的17β-雌二醇可降低血小板敏感性。给假手术雌性大鼠注射17β-雌二醇可增加血小板对ADP的敏感性。结果表明，生理量的雌激素在手术或应激后会导致血小板敏感性丧失，而较高浓度的雌激素会增加血小板敏感性。