Emms H, Lewis G P
Br J Pharmacol. 1985 Jan;84(1):243-8.
The effects of endogenous and exogenous, synthetic ovarian hormones on thrombus formation have been examined using an in vivo model in the rat. Thrombus formation in female rats was greatest during the di-oestrus stage of the oestrous cycle. Thrombus formation in both male and female rats was reduced following 6 weeks treatment with the oestrogen, ethynyl oestradiol whilst in females the progestogen, norethindrone acetate had no effect. These findings are in contrast to the increased risk of thromboembolic disorders reported in women taking oral contraceptives. The inhibitory effect of ethynyl oestradiol was not due to changes in blood flow but was dependent on the heparin concentration, being greatest at the highest heparin concentration used. Thrombus formation was greater in male rats than in females, a sex difference which is consistent with the higher incidence of cardiovascular disease in men than in women.
利用大鼠体内模型研究了内源性和外源性合成卵巢激素对血栓形成的影响。雌性大鼠的血栓形成在发情周期的间情期最为严重。用雌激素乙炔雌二醇治疗6周后，雄性和雌性大鼠的血栓形成均减少，而在雌性大鼠中，孕激素醋酸炔诺酮则没有效果。这些发现与服用口服避孕药的女性中报告的血栓栓塞性疾病风险增加形成对比。乙炔雌二醇的抑制作用并非由于血流变化，而是取决于肝素浓度，在所用最高肝素浓度时作用最大。雄性大鼠的血栓形成比雌性大鼠更严重，这种性别差异与男性心血管疾病发病率高于女性一致。
