Renna G, Siro-Brigiani G, Cuomo V
Toxicol Lett. 1981 Oct;9(2):107-12. doi: 10.1016/0378-4274(81)90025-4.
The effects of three aminoglycoside antibiotics on the rat isolated phrenic nerve-diaphragm preparation and on the sciatic nerve-gastrocnemius muscle preparation were investigated. Tobramycin, amikacin and ribostamycin produced dose-dependent neuromuscular blockade of the diaphragm twitches. Comparison of results showed that the neuromuscular blocking potency was as follows: tobramycin greater than amikacin greater than ribostamycin. The neuromuscular blockade produced gy these antibiotics was reversed by calcium chloride, whereas it was not influenced by neostigmine methylsulfate. Furthermore, the neuromuscular blocking potency in vitro of these three aminoglycosides was paralleled by their activity in vivo on the sciatic nerve-gastrocnemius muscle preparation.
研究了三种氨基糖苷类抗生素对大鼠离体膈神经-膈肌标本以及坐骨神经-腓肠肌标本的作用。妥布霉素、阿米卡星和核糖霉素对膈肌抽搐产生剂量依赖性的神经肌肉阻滞作用。结果比较显示，神经肌肉阻滞效能如下：妥布霉素大于阿米卡星大于核糖霉素。这些抗生素产生的神经肌肉阻滞作用可被氯化钙逆转，而不受甲硫酸新斯的明影响。此外，这三种氨基糖苷类抗生素在体外的神经肌肉阻滞效能与其在体内对坐骨神经-腓肠肌标本的作用平行。
