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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Xenobiotica. 1981 Aug;11(8):541-6. doi: 10.3109/00498258109045865.

The metabolism of 1,3-dibromopropane had been investigated in the rat. Two conjugated metabolites have been isolated from the urine and identified as S-(3-hydroxypropyl)cysteine and N-acetyl-S-(3-hydroxypropyl)cysteine. 2. An oxidation product, identified as beta-bromolactic acid, has been isolated as a urinary metabolite. 3. 1,3-dibromopropane is not excreted unchanged in expired air or in the urine. Approx. 15% of the dose (100 mg/kg) is excreted as metabolic products over 50 h and 3.5% as CO2 within 6 h, indicating that oxidation is the main route of detoxication.

已对大鼠体内1,3 - 二溴丙烷的代谢情况进行了研究。从尿液中分离出了两种共轭代谢物，鉴定为S -（3 - 羟丙基）半胱氨酸和N - 乙酰 - S -（3 - 羟丙基）半胱氨酸。2. 已分离出一种氧化产物，鉴定为β - 溴乳酸，作为尿液代谢物。3. 1,3 - 二溴丙烷不会以未改变的形式经呼气或尿液排出。大约15%的剂量（100毫克/千克）在50小时内作为代谢产物排出，3.5%在6小时内以二氧化碳形式排出，这表明氧化是主要的解毒途径。

Xenobiotica. 1981 Aug;11(8):541-6. doi: 10.3109/00498258109045865.

The metabolism of 1,3-dibromopropane had been investigated in the rat. Two conjugated metabolites have been isolated from the urine and identified as S-(3-hydroxypropyl)cysteine and N-acetyl-S-(3-hydroxypropyl)cysteine. 2. An oxidation product, identified as beta-bromolactic acid, has been isolated as a urinary metabolite. 3. 1,3-dibromopropane is not excreted unchanged in expired air or in the urine. Approx. 15% of the dose (100 mg/kg) is excreted as metabolic products over 50 h and 3.5% as CO2 within 6 h, indicating that oxidation is the main route of detoxication.

已对大鼠体内1,3 - 二溴丙烷的代谢情况进行了研究。从尿液中分离出了两种共轭代谢物，鉴定为S -（3 - 羟丙基）半胱氨酸和N - 乙酰 - S -（3 - 羟丙基）半胱氨酸。2. 已分离出一种氧化产物，鉴定为β - 溴乳酸，作为尿液代谢物。3. 1,3 - 二溴丙烷不会以未改变的形式经呼气或尿液排出。大约15%的剂量（100毫克/千克）在50小时内作为代谢产物排出，3.5%在6小时内以二氧化碳形式排出，这表明氧化是主要的解毒途径。