Wichmann T, Berndt K
Z Gesamte Inn Med. 1981 Jun 1;36(11):370-6.
The influence of genetic factors in the development of the coronary heart disease can be particularly impressively clarified at the instance of the primary hyperlipoproteinaemias. The exact diagnostics of the genetically determined disturbances of lipometabolism in patients with infarction is, however, still connected with difficulties. Determinations of serum cholesterol and triglycerides, lipid-electrophoretic recognitions as well as determinations of LDL- and HDL-cholesterol in the serum cannot always outline with utmost clearness the proportion of primary hyperlipoproteinaemias in the morbidity of infarctions. Before this background the practical value of the radiochemical screening test worked up at the model of lymphocytes is emphasized, which allows a clear diagnosis of primary forms of hypercholesterolaemia according to pathogenetic viewpoints and thus renders possible also family examinations within the primary prevention of the coronary heart disease.
在原发性高脂血症的情况下，遗传因素对冠心病发展的影响可以得到特别显著的阐明。然而，对梗死患者遗传决定的脂质代谢紊乱进行准确诊断仍存在困难。血清胆固醇和甘油三酯的测定、脂质电泳识别以及血清中低密度脂蛋白和高密度脂蛋白胆固醇的测定，并不总能极其清晰地勾勒出原发性高脂血症在梗死发病率中的比例。在此背景下，强调了以淋巴细胞为模型开发的放射化学筛查试验的实用价值，该试验能够根据发病机制观点明确诊断原发性高胆固醇血症的类型，从而也使冠心病一级预防中的家族检查成为可能。
