Marek Z, Bobula E
Z Rechtsmed. 1981;87(1-2):95-102. doi: 10.1007/BF00201214.
This paper tries to elucidate the mechanism of sudden death and myocardial infarction in the case of arteriosclerosis constricting the lumen of the vessels without obliteration. Two type of coronary arteriosclerosis can be differentiated: 1. The constrictions are limited to main coronary arteries; 2. The constrictions are found in small branches and precapillaries. In group 1 the reduction of blood flow depends on the systemic blood pressure. In group 2 the disturbances in blood distribution cannot by compensated by the rise in blood pressure. These phenomena can be elucidated by Kirchhoff's equations on the flow of liquid through elastic tubes and by comparison with elastic current flow or gas flow in pipeline net. Disturbances in the transport of nutritive substrates result in the non-uniform polarization of heart muscle fibers which leads to arrhythmias and acute insufficiency.
本文试图阐明在动脉硬化使血管腔狭窄但未闭塞的情况下猝死和心肌梗死的机制。可区分出两种类型的冠状动脉硬化:1. 狭窄局限于主要冠状动脉;2. 狭窄见于小分支和毛细血管前。在第1组中,血流减少取决于体循环血压。在第2组中,血压升高无法补偿血液分布的紊乱。这些现象可用基尔霍夫关于液体通过弹性管流动的方程来解释,并与管道网络中的弹性电流或气流进行比较。营养底物运输的紊乱导致心肌纤维极化不均匀,进而引发心律失常和急性功能不全。