Heine W, Peine D, Stolpe H J
Z Urol Nephrol. 1981 Jul;74(7):513-20.
The L-amino acid solution Infesol and the DL-amino solution Alvesin-new were one after the other investigated for their ability as a substitution of losses of amino acids conditioned by dialysis in 4 children with chronic renal insufficiency. The permanent intravenous drip infusion of 200 ml Infesol during 2 hours after the end of the haemodialysis led to a slight increase of the serum amino acids, which had normalized in a control 12 hours after the beginning of the infusion. The mean value of urea in the serum had increased after 2 hours by 17.60, after 12 hours by 3.65 mg compared with the initial value after the dialysis. The analogous infusion of Alvesin-new led to an on an average higher increase of the serum amino acids in the same patients. In the control after 12 hours the methionine-isoleucine, phenylalanine and arginine values in the serum were still significantly increased compared with the Infesol series. At the same time the mean value of serum urea increased by 80.95 mg/100 ml after two hours. After 12 hours it had increased by 105.5 mg/100 ml compared with the initial value. Thus, the solution of L-amino acid infesol is suitable for the compensation of losses of amino acids conditioned by dialysis. However, its application is reserved for larger dietetically not compensable condition of the lack of amino acids and protein.
对4名慢性肾功能不全儿童，先后研究了左旋氨基酸溶液英菲索尔（Infesol）和消旋氨基酸溶液新阿尔维辛（Alvesin - new）作为补充透析所致氨基酸损失的能力。血液透析结束后2小时内持续静脉滴注200 ml英菲索尔，可使血清氨基酸略有增加，在开始输注12小时后的对照中已恢复正常。与透析后的初始值相比，血清尿素平均值在2小时后增加了17.60，12小时后增加了3.65 mg。对同一患者类似地输注新阿尔维辛，可使血清氨基酸平均升高幅度更大。在12小时后的对照中，与英菲索尔组相比，血清中甲硫氨酸 - 异亮氨酸、苯丙氨酸和精氨酸值仍显著升高。同时，血清尿素平均值在两小时后增加了80.95 mg/100 ml。12小时后与初始值相比增加了105.5 mg/100 ml。因此，左旋氨基酸溶液英菲索尔适用于补充透析所致的氨基酸损失。然而，它仅适用于因饮食无法充分补充而导致的较大程度的氨基酸和蛋白质缺乏情况。
