Schneidkraut M J, Loegering D J
Adv Shock Res. 1980;3:273-82.
This study was carried out to evaluate the effects of hemolyzed blood and components of hemolyzed blood on RES function. Phagocytic index, determined using four different test particles in rats, was depressed 30 minutes following the injection of 0.3 ml/100 gm hemolyzed blood. Fractionation of hemolyzed blood into particulate and soluble fractions revealed that only the particulate material caused an RES depression. A decrease in phagocytic index was seen after the injection of hemoglobin-free erythrocyte ghosts, further indicating that the membrane components of hemolyzed blood are capable of depressing RES function. Injection of hemolyzed blood, as well as RES blockade, increased the mortality rate following endotoxin administration. Injection of hemoglobin had no effect on RES function or endotoxin shock susceptibility. It is concluded that hemolyzed blood causes a nonspecific depression in RES phagocytic function, as well as probably impairing endotoxin detoxification. These findings indicate that the hemolysis that accompanies burn injury may induce RES depression and increase susceptibility to shock states.
本研究旨在评估溶血血液及其成分对网状内皮系统（RES）功能的影响。在大鼠中使用四种不同的测试颗粒测定吞噬指数，在注射0.3 ml/100 gm溶血血液后30分钟，吞噬指数降低。将溶血血液分离为颗粒成分和可溶成分，结果显示只有颗粒物质会导致RES功能降低。注射无血红蛋白的红细胞膜后吞噬指数下降，进一步表明溶血血液的膜成分能够降低RES功能。注射溶血血液以及阻断RES，均会增加内毒素给药后的死亡率。注射血红蛋白对RES功能或内毒素休克易感性没有影响。结论是，溶血血液会导致RES吞噬功能出现非特异性降低，并且可能损害内毒素解毒功能。这些发现表明，烧伤损伤伴随的溶血可能会导致RES功能降低，并增加对休克状态的易感性。
