Waschek J, Hinkle G, Basmadjian G, Allen E W, Ice R
Am J Hosp Pharm. 1981 Nov;38(11):1726-8.
The effects of commonly used cardiac drugs on cardiac imaging with thallium-201-labeled thallous chloride were studied. This retrospective study included 62 men ranging in age from 37 to 70 years who had cardiac imaging attempted with thallium during an eight-month period. Seven drugs were being used by at least eight patients each--propranolol, nitroglycerin ointment, isosorbide dinitrate, digoxin, hydrochlorothiazide, potassium chloride, and quinidine. Myocardial-to-background (M/Bk) ratios were calculated for each patient. No drug consistently affected the M/Bk ratios. The lowest M/Bk ratio was found in patients receiving digoxin, but there was no significant difference between the M/Bk ratios for patients taking digoxin (1.38 +/- 0.16) and those not taking digoxin (1.45 +/- 0.10) (0.05 less than p less than 0.10, Student's t test). It is concluded that the drugs studied do not affect cardiac imaging with thallous chloride Tl 201.
研究了常用心脏药物对201铊标记氯化亚铊心脏成像的影响。这项回顾性研究纳入了62名年龄在37至70岁之间的男性，他们在八个月的时间里接受了铊心脏成像检查。至少有8名患者使用了7种药物——普萘洛尔、硝酸甘油软膏、硝酸异山梨酯、地高辛、氢氯噻嗪、氯化钾和奎尼丁。计算了每位患者的心肌与本底（M/Bk）比值。没有一种药物能持续影响M/Bk比值。接受地高辛治疗的患者M/Bk比值最低，但服用地高辛的患者（1.38±0.16）与未服用地高辛的患者（1.45±0.10）的M/Bk比值之间没有显著差异（0.05＜p＜0.10，Student t检验）。结论是，所研究的药物不影响氯化亚铊Tl 201心脏成像。
