Farcot J M, Laugner B, Muller A
Anesth Analg (Paris). 1981;38(7-8):351-5.
Low dose morphine epidurals (0.5 to 4 mg) provide a good way of controlling either per or postoperative pain (210 cases) or chronic, somatic, intractable pain (282 cases). Selective and metameric medullar hypoalgesia is induced at a level which varies with the level of injection. There is an acquired tolerance which restricts the use of such injections to the short-term monitoring of somatic pain. In other types of psychogenic and deafferentiation pain, there is little or no sedation, but there are maximum secondary dysphoric effects. The degree of combination of these dysphoric effects with hypoalgesia is of diagnostic interest of the type of pain involved, and of prognostic interest when both somatic and deafferentation pains are present.
低剂量吗啡硬膜外注射（0.5至4毫克）为控制围手术期疼痛（210例）或慢性、躯体性、顽固性疼痛（282例）提供了一种良好的方法。在不同注射水平会诱导出选择性和节段性脊髓痛觉减退。存在后天耐受性，这限制了此类注射仅用于躯体疼痛的短期监测。在其他类型的心理性和去传入性疼痛中，几乎没有或没有镇静作用，但有最大程度的继发性烦躁不安效应。这些烦躁不安效应与痛觉减退的组合程度对于所涉及的疼痛类型具有诊断意义，而当同时存在躯体性和去传入性疼痛时则具有预后意义。
