Labie D, Elion J
Ann Biol Clin (Paris). 1981;39(4):197-203.
The study of abnormal hemoglobins was oriented towards three criteria as a function of commonly encountered clinical problems : differentiation between frequent, relatively infrequent and exceptional hemoglobins ; systematic study of high-risk ethnic groups and isolated discoveries ; silent hemoglobinopathies and those accompanied by physiopathological repercussions such as hemolytic anemia, disturbance in oxygen transport and cyanosis. The chronology and rationale for these studies was discussed, with particular attention being given both to normalized baseline measures and to the new, high-resolution techniques such as isoelectric focalization. No attempt was made to provide an exhaustive list, but rather examples were provided illustrating the various points considered. Finally, a number of particular points are brought up to where a correctly made diagnosis can avoid the necessity of subjecting patients to long and possibly dangerous tests.
异常血红蛋白的研究针对三个标准，这是根据常见的临床问题确定的：区分常见、相对少见和罕见的血红蛋白；对高危种族群体进行系统研究以及孤立发现；无症状血红蛋白病以及那些伴有溶血性贫血、氧运输障碍和发绀等生理病理影响的血红蛋白病。讨论了这些研究的时间顺序和基本原理，特别关注了标准化基线测量以及等电聚焦等高分辨率新技术。本文并未试图提供详尽的清单，而是给出了说明所考虑的各个要点的示例。最后，提出了一些特殊要点，正确的诊断可避免让患者接受冗长且可能危险的检查。
