Suchkova G S, Lokshin G B, Kliuev N A, Kuzovkov A D, Shilova S V
Antibiotiki. 1981 Oct;26(10):731-5.
The effect of oxygen and moisture on stability of sodium fusidate was studied. It was shown that inactivation of the antibiotic in the atmosphere of oxygen was due to its oxidation in the preparations with low humidity levels. In the preparations with high humidity levels, the main cause of the antibiotic inactivation was hydrolysis with respect to C-16-O-acetyl group. When sodium fusidate was air stored, the salts of 24, 25-dioxy-and 24, 25-dioxy-11-monoketofusidic acids were identified among the products of its inactivation. The salts of 24,25-dioxy-11-monoketofusidic acid were also prepared by oxidation of fusidic acid with potassium permanganate in a weak alkaline medium. The possibility of using sodium sulfite and metabisulfite as stabilizers for th antibiotic storage was shown.
研究了氧气和水分对夫西地酸钠稳定性的影响。结果表明，在低湿度水平的制剂中，抗生素在氧气氛围中的失活是由于其氧化作用。在高湿度水平的制剂中，抗生素失活的主要原因是C-16-O-乙酰基的水解。当夫西地酸钠在空气中储存时，在其失活产物中鉴定出了24,25-二氧代-和24,25-二氧代-11-单酮夫西地酸的盐。24,25-二氧代-11-单酮夫西地酸的盐也通过在弱碱性介质中用高锰酸钾氧化夫西地酸来制备。结果表明，亚硫酸钠和焦亚硫酸钠可作为该抗生素储存的稳定剂。
