Southworth G R, Keffer C C, Beauchamp J J
Arch Environ Contam Toxicol. 1981 Sep;10(5):561-9. doi: 10.1007/BF01054879.
The bioconcentration and metabolism of benz(a)acridine in fathead minnows (Pimephales promelas) was investigated using 14C-labelled benz(a)acridine. The rates of uptake, elimination, and metabolic transformation of benz(a)acridine were estimated in the fish. The equilibrium concentration factor [ratio of benz(a)acridine concentration in fish (wet weight) to benz(a)acridine concentration in water] was estimated at 106 +/- 17. The observed bioconcentration factor was about one tenth of that predicted by octanol-water partitioning models. Metabolic alteration was estimated to reduce the degree of bioconcentration 50 to 90% from the hypothetical case in which metabolic transformation did not occur. Benz(a)acridine metabolites attained concentrations in the fish considerably in excess of benz(a)acridine itself.
使用14C标记的苯并(a)吖啶研究了其在黑头呆鱼（Pimephales promelas）中的生物富集和代谢情况。对鱼体内苯并(a)吖啶的摄取、消除和代谢转化速率进行了估算。平衡浓度因子[鱼体（湿重）中苯并(a)吖啶浓度与水中苯并(a)吖啶浓度之比]估算为106±17。观察到的生物富集因子约为辛醇-水分配模型预测值的十分之一。据估计，代谢改变使生物富集程度比未发生代谢转化的假设情况降低了50%至90%。苯并(a)吖啶代谢物在鱼体内达到的浓度大大超过了苯并(a)吖啶本身。
