Dean R H, Kieffer R W, Smith B M, Oates J A, Nadeau J H, Hollifield J W, DuPont W D
Arch Surg. 1981 Nov;116(11):1408-15. doi: 10.1001/archsurg.1981.01380230032005.
Serial renal function studies were performed on 41 patients wtih renovascular hypertension (RVH) secondary to atherosclerotic renal artery disease who had been randomly selected for nonoperative management. In 19 patients, serum creatinine levels increased between 25% and 120%. The glomerular filtration rates dropped between 25% and 50% in 12 patients. Fourteen patients (37%) lost more than 10% of renal length. In four patients (12%), a significant stenosis progressed to total occlusion. Seventeen patients (41%) had deterioration of renal function or loss of renal size that led to operation. One patient required removal of a previously reconstructible kidney. Of the 17 patients with deterioration, 15 had acceptable blood pressure (BP) control during the period of nonoperative observation. Progressive deterioration of renal function in nonoperatively treated patients with atherosclerotic renal artery stenosis and RVH is common, and occurs even in the presence of BP control with drugs.
对41例因动脉粥样硬化性肾动脉疾病继发肾血管性高血压（RVH）且被随机选入非手术治疗的患者进行了系列肾功能研究。19例患者的血清肌酐水平升高了25%至120%。12例患者的肾小球滤过率下降了25%至50%。14例患者（37%）肾长度减少超过10%。4例患者（12%）的严重狭窄进展为完全闭塞。17例患者（41%）出现肾功能恶化或肾体积缩小而需要手术。1例患者需要切除先前可重建的肾脏。在17例病情恶化的患者中，15例在非手术观察期间血压（BP）控制良好。在非手术治疗的动脉粥样硬化性肾动脉狭窄和RVH患者中，肾功能进行性恶化很常见，甚至在药物控制血压的情况下也会发生。
