人红细胞中细胞色素b5和细胞色素b5还原酶的年龄依赖性衰减。
Age-dependent decay of cytochrome b5 and cytochrome b5 reductase in human erythrocytes.
作者信息
Matsuki T, Tamura M, Takeshita M, Yoneyama Y
出版信息
Biochem J. 1981 Jan 15;194(1):327-30. doi: 10.1042/bj1940327.
Abstract
Age-dependent decrease in cytochrome b5 was observed in erythrocytes from both a normal person and a patient with hereditary methaemoglobinaemia without neurological symptoms. With aging, concentrations of cytochrome b5 in erythrocytes from the patient were almost the same as those in the control. Age-dependent decrease in cytochrome b5 reductase activity in the control erythrocytes was also shown; however, the reductase activity was very low in erythrocytes from the patient over the whole age range. Our studies show that methaemoglobin content of erythrocytes seems to be dependent on the content of cytochrome b5 in the cells, both in the control subject and in the patient.
摘要
在一名正常人以及一名无神经症状的遗传性高铁血红蛋白血症患者的红细胞中，均观察到细胞色素b5随年龄增长而减少。随着年龄增长，患者红细胞中细胞色素b5的浓度与对照组几乎相同。对照组红细胞中细胞色素b5还原酶活性也呈现出随年龄增长而降低的趋势；然而，在整个年龄范围内，患者红细胞中的还原酶活性都非常低。我们的研究表明，无论是在对照组还是患者中，红细胞的高铁血红蛋白含量似乎都取决于细胞中细胞色素b5的含量。
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本文引用的文献
1
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Clin Chim Acta. 1965 Apr;11:334-40. doi: 10.1016/0009-8981(65)90223-8.
2
DETERMINATION OF DENSITY DISTRIBUTION OF RED CELL POPULATION.红细胞群体密度分布的测定
J Lab Clin Med. 1964 Oct;64:668-74.
3
Characterization of the purified NADH-cytochrome b5 reductase of human erythrocytes as a FAD-containing enzyme.
J Biol Chem. 1980 Mar 25;255(6):2454-6.
4
NADH-cytochrome b5 reductase in platelets and leukocytes with special reference to normal levels and to levels in carriers of hereditary methemoglobinemia with or without neurological symptoms.
Acta Haematol. 1980;63(1):7-12. doi: 10.1159/000207361.
5
Red-cell "pseudomosaicism" in congenital methemoglobinemia.先天性高铁血红蛋白血症中的红细胞“假镶嵌现象”
N Engl J Med. 1966 Aug 25;275(8):397-405. doi: 10.1056/NEJM196608252750801.
6
Erythocyte destruction and hemoglobin catabolism.
Semin Hematol. 1972 Jan;9(1):3-17.
7
Congenital methemoglobinemia: the result of age-dependent decay of methemoglobin reductase.
Blood. 1972 Mar;39(3):407-14.
8
Purification of reduced pyridine nucleotide dehydrogenase from human erythrocytes and methemoglobin reduction by the enzyme.从人红细胞中纯化还原型吡啶核苷酸脱氢酶及其对高铁血红蛋白的还原作用。
J Biol Chem. 1971 Oct 10;246(19):6072-8.
9
Activity of NADH- and NADPH-dependent methemoglobin reductases in erythrocytes from fetal to adult age. A parallel assessment.从胎儿到成人阶段红细胞中NADH和NADPH依赖性高铁血红蛋白还原酶的活性。一项平行评估。
Klin Wochenschr. 1971 Sep 1;49(17):972-7. doi: 10.1007/BF01489462.
10
Relationship between age and properties of human and rabbit erythrocyte glucose-6-phosphate dehydrogenase.人类和兔红细胞葡萄糖-6-磷酸脱氢酶的年龄与特性之间的关系
Eur J Biochem. 1969 Jan;7(2):214-22. doi: 10.1111/j.1432-1033.1969.tb19594.x.
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