人红细胞中细胞色素b5和细胞色素b5还原酶的年龄依赖性衰减。
Age-dependent decay of cytochrome b5 and cytochrome b5 reductase in human erythrocytes.
作者信息
Matsuki T, Tamura M, Takeshita M, Yoneyama Y
出版信息
Biochem J. 1981 Jan 15;194(1):327-30. doi: 10.1042/bj1940327.
Abstract
Age-dependent decrease in cytochrome b5 was observed in erythrocytes from both a normal person and a patient with hereditary methaemoglobinaemia without neurological symptoms. With aging, concentrations of cytochrome b5 in erythrocytes from the patient were almost the same as those in the control. Age-dependent decrease in cytochrome b5 reductase activity in the control erythrocytes was also shown; however, the reductase activity was very low in erythrocytes from the patient over the whole age range. Our studies show that methaemoglobin content of erythrocytes seems to be dependent on the content of cytochrome b5 in the cells, both in the control subject and in the patient.
摘要
在一名正常人以及一名无神经症状的遗传性高铁血红蛋白血症患者的红细胞中，均观察到细胞色素b5随年龄增长而减少。随着年龄增长，患者红细胞中细胞色素b5的浓度与对照组几乎相同。对照组红细胞中细胞色素b5还原酶活性也呈现出随年龄增长而降低的趋势；然而，在整个年龄范围内，患者红细胞中的还原酶活性都非常低。我们的研究表明，无论是在对照组还是患者中，红细胞的高铁血红蛋白含量似乎都取决于细胞中细胞色素b5的含量。
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