慢性氟哌啶醇和舒必利治疗对大鼠黑质γ-氨基丁酸含量的影响。
Effects of chronic haloperidol and sulpiride treatment on rat nigral GABA content.
作者信息
Rampello L, Giammona G, Patti F, Reggio A, Nicoletti F, Di Giorgio R M, Condorelli D F
出版信息
Boll Soc Ital Biol Sper. 1981 Aug 15;57(15):1608-11.
PMID:7306401
Abstract
The effects of chronic haloperidol and sulpiride treatment on nigral GABA content were investigated in rats. Chronic sulpiride treatment is capable of inducing an increase in nigral GABA content whilst no significant effect is observed following chronic haloperidol treatment at the doses used. The different effects of haloperidol and sulpiride on nigral GABA content were related to the different neuropharmacological spectrum of the two drugs.
摘要
研究了慢性给予氟哌啶醇和舒必利对大鼠黑质γ-氨基丁酸（GABA）含量的影响。慢性给予舒必利能够使黑质GABA含量增加，而在所使用的剂量下，慢性给予氟哌啶醇后未观察到显著影响。氟哌啶醇和舒必利对黑质GABA含量的不同影响与这两种药物不同的神经药理学特性有关。
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