慢性氟哌啶醇和舒必利治疗对黑质和纹状体γ-氨基丁酸含量的比较影响。

Comparative effects of chronic haloperidol and sulpiride treatment on nigral and striatal GABA content.

作者信息

Nicoletti F, Patti F, Condorelli D F, Rampello L, Giammona G, Di Giorgio R M, Canonico P L, Scapagnini U

出版信息

J Neurochem. 1981 Oct;37(4):1048-51. doi: 10.1111/j.1471-4159.1981.tb04495.x.

DOI:10.1111/j.1471-4159.1981.tb04495.x

PMID:7320718

Abstract

Nigral and striatal GABA contents were assayed in male rats treated chronically with haloperidol or sulpiride, two dopamine-receptor blocking agents that have different neuropharmacological spectra in regard to their biochemical, behavioural, and clinical properties. No great difference was observed between the chronic effects of haloperidol and sulpiride on nigral and striatal GABA content. However, low doses (30 micrograms/kg, intraperitoneally) of the dopamine-receptor agonist apomorphine, injected 12 h after the discontinuation of chronic haloperidol or chronic sulpiride treatment, induced opposite changes in nigral GABA levels suggesting the existence of a different "status" of the dopamine receptors during the 12 h-period following the withdrawal of haloperidol or sulpiride.

摘要

在长期接受氟哌啶醇或舒必利治疗的雄性大鼠中测定黑质和纹状体的γ-氨基丁酸（GABA）含量。氟哌啶醇和舒必利是两种多巴胺受体阻断剂，就其生化、行为和临床特性而言，它们具有不同的神经药理学谱。未观察到氟哌啶醇和舒必利对黑质和纹状体GABA含量的慢性影响有很大差异。然而，在慢性氟哌啶醇或慢性舒必利治疗停药12小时后注射低剂量（30微克/千克，腹腔注射）的多巴胺受体激动剂阿扑吗啡，会引起黑质GABA水平的相反变化，这表明在停用氟哌啶醇或舒必利后的12小时内，多巴胺受体存在不同的“状态”。