Baldoni F, Tallarida G, Peruzzi G, Raimondi G, Massaro M, Sangiorgi M
Boll Soc Ital Biol Sper. 1981 Aug 30;57(16):1680-6.
In 15 anesthetized rabbits the reflex changes in arterial pressure, heart rate and respiratory rate in response to injections of bradykinin inorganic phosphate and prostaglandins into femoral artery have been studied. Intraarterial injection of bradykinin produced a reflex fall in arterial pressure, bradycardia and tachypnea. The latency of response ranged from 6 to 7 sec. The threshold dose was about 50 ng. This effect was accompanied by a consistent increase in the afferent discharge in the saphenus nerve. Isotonic mixtures of Na2HPO4 and NaH2PO4 at pH 7, PGE1, PGE2, and PGA, when injected into femoral artery even in high doses, failed to produce any significant cardiocirculatory or respiratory reflex responses. Infusion of PGE1 (1 ug/min) into femoral artery, although inactive by itself, enhanced the reflex effect of bradykinin.
在15只麻醉兔中，研究了向股动脉注射缓激肽、无机磷酸盐和前列腺素后动脉血压、心率和呼吸频率的反射性变化。动脉内注射缓激肽可引起动脉血压反射性下降、心动过缓和呼吸急促。反应潜伏期为6至7秒。阈剂量约为50纳克。这种效应伴随着隐神经传入放电的持续增加。pH值为7的Na2HPO4和NaH2PO4的等渗混合物、PGE1、PGE2和PGA，即使大剂量注入股动脉，也未能产生任何明显的心脏循环或呼吸反射反应。向股动脉输注PGE1（1微克/分钟），虽然其本身无活性，但可增强缓激肽的反射效应。
