Barbato F, Cappello B, Recanatini M, Silipo C, Vittoria A
Boll Soc Ital Biol Sper. 1981 Sep 15;57(17):1800-6.
The 1-octanol/water partition coefficients of sets of 1,4-benzodiazepine and phenothiazine derivatives are determined. The values of the hydrophobic parameters obtained by shake-flask procedure are correlated to the corresponding HPLC retention times. The existence of linear correlations between the two experimentally determined parameters clearly show that chromatographic indices model excellently the shake-flask parameters.
测定了1,4 - 苯二氮䓬和吩噻嗪衍生物组的正辛醇/水分配系数。通过摇瓶法获得的疏水参数值与相应的高效液相色谱保留时间相关。这两个实验测定参数之间存在线性相关性，清楚地表明色谱指标模型能很好地模拟摇瓶参数。
