II型假性甲状旁腺功能减退症中的基底节钙化。

Basal ganglia calcification in pseudohypoparathyroidism type II.

作者信息

Windeck R, Menken U, Benker G, Reinwein D

出版信息

Clin Endocrinol (Oxf). 1981 Jul;15(1):57-63. doi: 10.1111/j.1365-2265.1981.tb02748.x.

DOI:10.1111/j.1365-2265.1981.tb02748.x

Abstract

The case history of a patient with basal ganglia calcifications found by computerised tomography is presented. Calcium and phosphorus metabolism showed a pattern suggesting lack of parathyroid hormone (PTH). Further studies revealed increased endogenous PTH levels and urinary cAMP excretion. However, endogenous and exogenous PTH could not elicit the cAMP-mediated phosphaturic response, indicating pseudohypoparathyroidism type II. The responses of prolactin to TRH and chlorpromazine was impaired. Basal ganglia calcification in pseudohypoparathyroidism type II may represent the only somatic abnormality in this disease apart from the biochemical abnormalities.

摘要

本文介绍了一名通过计算机断层扫描发现基底节钙化患者的病例史。钙和磷代谢呈现出提示甲状旁腺激素（PTH）缺乏的模式。进一步研究显示内源性PTH水平升高和尿cAMP排泄增加。然而，内源性和外源性PTH均不能引发cAMP介导的磷尿反应，提示为II型假性甲状旁腺功能减退症。催乳素对促甲状腺激素释放激素（TRH）和氯丙嗪的反应受损。II型假性甲状旁腺功能减退症中的基底节钙化可能是除生化异常外该疾病唯一的躯体异常表现。