吡咯他尼与大鼠尿液中离子的排泄。吲哚美辛的影响。

Piretanide and urinary excretion of ions in rat. Effect of indomethacin.

Nguyen-Simonnet H, Gauthier C, Pellet M

Clin Exp Pharmacol Physiol. 1981 Jul;8(4):315-25. doi: 10.1111/j.1440-1681.1981.tb00735.x.

Abstract

Piretanide is a new loop diuretic resembling furosemide. The effects of this diuretic on various parameters of renal function and on the excretion of the major ions were studied on anaesthetized, hydrated rats. 2. Piretanide induced a marked diuresis and increased sodium, potassium, chloride and calcium excretion. Calcium excretion increased more than that of sodium. Urinary osmolality and water reabsorption decreased. 3. Inulin clearance and phosphate excretion were significantly altered by piretanide. 4. Pretreatment of rats with indomethacin did not suppress the effects of piretanide on diuresis nor its effects on urinary excretion of sodium, chloride and potassium, since these parameters increased in the same proportion in the presence or in the absence of indomethacin. 5. Pretreatment with indomethacin abolished piretanide-induced dissociation of sodium and calcium excretions.

摘要

吡咯他尼是一种类似呋塞米的新型袢利尿剂。在麻醉、补水的大鼠身上研究了这种利尿剂对各种肾功能参数及主要离子排泄的影响。2. 吡咯他尼引起显著的利尿作用，并增加钠、钾、氯和钙的排泄。钙排泄量的增加超过钠。尿渗透压和水重吸收降低。3. 吡咯他尼显著改变菊粉清除率和磷酸盐排泄。4. 用吲哚美辛预处理大鼠并未抑制吡咯他尼的利尿作用及其对尿钠、氯和钾排泄的影响，因为在有或没有吲哚美辛的情况下，这些参数以相同比例增加。5. 用吲哚美辛预处理消除了吡咯他尼引起的钠和钙排泄的分离。