Wadlington W B, Erlendson I W, Burr I M
Clin Pediatr (Phila). 1981 Dec;20(12):804-6. doi: 10.1177/000992288102001209.
A 17-year-old black female developed Sydenham's chorea 8 weeks after inaugurating the daily use of an oral contraceptive. Two weeks after she stopped the oral contraceptive, her signs and symptoms of chorea disappeared. Other causes of chorea were eliminated by various lab tests and a 4-year follow-up on the patient. Phenytoin sodium and methadone are cited as two other medications that have been associated with drug-induced chorea. Some theories are presented about altered dopaminergic sensitivity by various drugs that could produce choreic movements. The literature of chorea associated with oral contraceptives is reviewed. The pediatrician is reminded to consider side effects of oral contraceptives when dealing with a sick teenager.
一名17岁黑人女性在开始每日服用口服避孕药8周后出现了 Sydenham 舞蹈症。在她停止服用口服避孕药两周后，舞蹈症的体征和症状消失了。通过各种实验室检查以及对该患者进行的4年随访，排除了其他导致舞蹈症的病因。苯妥英钠和美沙酮被列为另外两种与药物性舞蹈症有关的药物。文中提出了一些关于各种药物改变多巴胺能敏感性从而可能导致舞蹈样动作的理论。对与口服避孕药相关的舞蹈症文献进行了综述。提醒儿科医生在诊治患病青少年时要考虑口服避孕药的副作用。
