Shepherd A, Lin M S, McNay J, Ludden T, Musgrave G
Clin Pharmacol Ther. 1981 Dec;30(6):773-81. doi: 10.1038/clpt.1981.237.
There is marked interindividual variation in hypotensive response to intravenous hydralazine (H). We examined the determinants of response in patients with hypertension. After a single intravenous dose of 0.3 mg/kg H, response was correlated independently (r = 0.8364) with both predrug blood pressure and acetylator index (AI). Intravenous dose ranging studies showed that response also depended on the amount of H in the systemic circulation. Although plasma H levels depend on AI after oral doses, this is not so after intravenous administration. AI must therefore affect response to H by an alternative, presumably nonmetabolic mechanism which, not related to AI, perhaps indicating specificity of this effect for H. These data reinforce the potential usefulness of determining AI before giving H to a patient.
静脉注射肼屈嗪（H）后，个体间的降压反应存在显著差异。我们研究了高血压患者反应的决定因素。单次静脉注射0.3mg/kg H后，反应与用药前血压和乙酰化指数（AI）均独立相关（r = 0.8364）。静脉剂量范围研究表明，反应还取决于体循环中H的量。虽然口服给药后血浆H水平取决于AI，但静脉给药后并非如此。因此，AI必须通过一种替代机制影响对H的反应，推测该机制可能是非代谢性的，与AI无关，这可能表明这种效应对H具有特异性。这些数据强化了在给患者使用H之前测定AI的潜在实用性。
