Gupta U, Malhotra N, Varma S K, Chaudhury R R
Contraception. 1981 Sep;24(3):283-8. doi: 10.1016/0010-7824(81)90041-x.
Three antiprostaglandin drugs, acetylsalicylic acid, indomethacin and ibuprofen, were administered intraluminally at different does to pregnant rats on Day 4 of pregnancy. It was observed that ibuprofen administered at a dose of 400 micrograms inhibited implantation in all rats. Ibuprofen when administered at a lower dose of 100 or 200 micrograms on Day 4 of pregnancy or at a dose of 400 micrograms on Day 3 or 5 of pregnancy did not exert such an antiimplantation effect. Acetylsalicylic acid and indomethacin also induced, but to a lesser extent, an antiimplantation effect when administered at a dose of 400 micrograms on Day 4 of pregnancy.
在妊娠第4天，对怀孕大鼠经腔内给予三种抗前列腺素药物，即阿司匹林、吲哚美辛和布洛芬，给予不同剂量。观察到，以400微克的剂量给予布洛芬会抑制所有大鼠的着床。在妊娠第4天以100或200微克的较低剂量给予布洛芬，或在妊娠第3天或第5天以400微克的剂量给予布洛芬，均未产生这种抗着床作用。阿司匹林和吲哚美辛在妊娠第4天以400微克的剂量给药时，也会诱导抗着床作用，但程度较轻。
