Wright A F, Rose M S
Dev Toxicol Environ Sci. 1980;8:639-42.
The in vitro incorporation of 14C-glycine into haem, and 35S-sulphate into macromolecules have been investigated as biochemical measurements with the potential to reflect the proportion of certain erythroid and myeloid cells within rat bone marrow. Erythroid hyperplasia caused an increase of haem synthesis and a concomitant decrease in 35S-sulphate incorporation. Erythroid hypoplasia reduced haem synthesis and increased 35S-sulphate incorporation. The measures of haem synthesis and 35S-sulphate incorporation thus provide useful tools for detecting specific changes in cell populations in rat bone marrow suspensions.
对14C-甘氨酸在体外掺入血红素以及35S-硫酸盐在体外掺入大分子的情况进行了研究，以此作为生化检测手段，其有可能反映大鼠骨髓中某些红系和髓系细胞的比例。红系增生导致血红素合成增加，同时35S-硫酸盐掺入减少。红系发育不全则使血红素合成减少，35S-硫酸盐掺入增加。因此，血红素合成和35S-硫酸盐掺入的检测手段为检测大鼠骨髓悬液中细胞群体的特定变化提供了有用的工具。
