大鼠组织中 T4 向 T3 转化活性与 T3 浓度的相关性。

Correlation of T4 to T3 converting activity with T3 concentration in rat tissues.

作者信息

Imai Y, Yamauchi K, Kitahara H, Nishikimi M

出版信息

Endocrinol Jpn. 1981 Jun;28(3):271-6. doi: 10.1507/endocrj1954.28.271.

DOI:10.1507/endocrj1954.28.271

Abstract

The correlation between T4 5'-deiodinase activity and thyroid hormone concentration in rat tissues was sought. Studies with normal and thyroidectomized rats indicated a significant correlation of the hepatic T3 concentration with the enzyme activity in liver homogenate (r = 0.80, p less than 0.01) or in liver microsomes (r = 0.08, p less than 0.01). The correlation between the hepatic T4 concentration and activity of the enzyme was less significant (r = 0.55, p less than 0.05 for homogenate, and r = 0.66, p less than 0.01 for microsomes). The degree of T4 5'-deiodinase activity in various organs was found to increase in line with tissue concentration of T3. It seems likely that the level of T4 5'-deiodinase activity is controlled by the tissue concentration of T3.

摘要

研究了大鼠组织中T4 5'-脱碘酶活性与甲状腺激素浓度之间的相关性。对正常大鼠和甲状腺切除大鼠的研究表明，肝脏T3浓度与肝脏匀浆（r = 0.80，p < 0.01）或肝脏微粒体（r = 0.80，p < 0.01）中的酶活性显著相关。肝脏T4浓度与该酶活性之间的相关性较小（匀浆中r = 0.55，p < 0.05；微粒体中r = 0.66，p < 0.01）。发现各器官中T4 5'-脱碘酶活性的程度与T3的组织浓度一致增加。T4 5'-脱碘酶活性水平似乎受T3组织浓度的控制。