Moorthi K, Wiederholt K
Eur J Clin Pharmacol. 1981;20(1):35-8. doi: 10.1007/BF00554664.
The levels of doxycycline in serum, bile and the gallbladder wall were determined in 25 patients during cholecystectomy, by means of bioassay after previous intravenous administration of doxycycline. The mean biliary level exceeded 20 microgram/ml, and the mean level in the gallbladder wall was greater than 2 microgram/g. With few exceptions all the levels found clearly exceeded the MIC of most relevant pathogens. This was confirmed by the levels found in bile drained via T-Tube. Thus, clinically important breakdown of doxycycline by the mainly alkaline bile acids should not be anticipated.
在25例患者胆囊切除术中，于静脉注射强力霉素后，通过生物测定法测定血清、胆汁及胆囊壁中强力霉素的水平。胆汁平均水平超过20微克/毫升，胆囊壁平均水平大于2微克/克。除少数例外情况，所测得的所有水平均明显超过大多数相关病原体的最低抑菌浓度。经T管引流胆汁中的水平证实了这一点。因此，不应预期主要碱性胆汁酸会导致临床上重要的强力霉素分解。
