Blackhall M I, Macartney B, O'Donnell S R
Eur J Respir Dis. 1981 Aug;62(4):268-75.
Ten asthmatic children received regular daily therapy with terbutaline aerosol for 50 weeks. No evidence was found for adverse effects of this drug on growth, bone marrow, liver function or the cardiovascular system. All children had improved respiratory function throughout the year. In acute experiments carried out in 12 symptom-free asthmatic children with 0.5 mg terbutaline, it was demonstrated that the improvement in respiratory function, i.e. increase in FEV1, MMEF25-75%, FVC and PEF, was quick in onset, was maintained for at least 60 min and was not accompanied by effects on pulse rate. Thus, the bronchodilator aerosol, terbutaline, can be safely used as a regular daily therapy in asthmatic children aged 7 to 14 years.
十名哮喘儿童接受了为期50周的每日常规特布他林气雾剂治疗。未发现该药物对生长、骨髓、肝功能或心血管系统有不良影响。所有儿童全年呼吸功能均有改善。在12名无症状哮喘儿童中进行的急性实验中，给予0.5毫克特布他林，结果表明呼吸功能的改善，即第一秒用力呼气量（FEV1）、25%-75%用力呼气中期流速（MMEF25-75%）、用力肺活量（FVC）和呼气峰值流速（PEF）增加，起效迅速，至少维持60分钟，且未伴有心率变化。因此，支气管扩张气雾剂特布他林可安全地用于7至14岁哮喘儿童的每日常规治疗。
