West M O, Christian E, Robinson J H, Deadwyler S A
Exp Brain Res. 1981;44(3):287-94. doi: 10.1007/BF00236566.
The activity of dentate granule cells (g-cells) was recorded in chronic rats during single-tone sensory discrimination performance. Attempts to correlate the discharge pattern of dentate g-cells with (1) the onset of the conditioned tone stimulus, (2) movements of the animals during the conditioning trials, (3) the occurrence of the reinforced response, and (4) the presence or absence of theta rhythm during the trial revealed several features of g-cell discharge during performance of operant sensory discrimination. The most consistent finding was that g-cells were driven at short latencies (40-60 ms) by the onset of the tone stimulus in the absence of detectable body movements. A subsequent, less intense sustained discharge of g-cells was shown to be unrelated to the onset of (1) conditioned movements during the trial, or (2) the execution of the conditioned response. Thus neither phase of g-cell discharge to the tone stimulus appeared to be a direct correlate of inadvertently or directly conditioned movements in this experimental paradigm. Theta rhythm, which accompanied certain movements prior to the execution of the operant response, did not correlate with the initial phase of g-cell discharge but appeared to modulate the subsequent phase of sustained g-cell activity.
在慢性大鼠进行单音感觉辨别任务期间，记录了齿状颗粒细胞（g细胞）的活动。试图将齿状g细胞的放电模式与以下因素相关联：（1）条件性音调刺激的开始；（2）条件化试验期间动物的运动；（3）强化反应的发生；以及（4）试验期间θ节律的存在与否，这些揭示了操作性感觉辨别任务执行期间g细胞放电的几个特征。最一致的发现是，在没有可检测到的身体运动的情况下，g细胞在短潜伏期（40 - 60毫秒）时被音调刺激的开始所驱动。随后，g细胞持续的、强度较低的放电被证明与以下因素无关：（1）试验期间的条件性运动的开始，或（2）条件反应的执行。因此，在这个实验范式中，g细胞对音调刺激的放电的两个阶段似乎都不是无意或直接条件性运动的直接相关因素。在操作性反应执行之前伴随某些运动的θ节律，与g细胞放电的初始阶段不相关，但似乎调节了g细胞持续活动的后续阶段。
