Leaton R N, Jordan W P
J Comp Physiol Psychol. 1978 Oct;92(5):803-14. doi: 10.1037/h0077538.
Presentation of auditory stimuli over interstimulus intervals (ISIs) of several minutes to sleeping rats produced significant habituation of the electroencephalographic (EEG) arousal response. The arousal response habituated to an asymptote after only two or three stimulus presentations. Little or no spontaneous recovery occurred between sessions separated by 24 or 72 hr. The habituation produced by a single stimulus presentation was retained for at least 24 hr, and orderly habituation was shown with a 24-hr ISI. Approximately 90% retention of habituation was shown 32 days following 10 stimulus presentations, and some degree of retention was shown for as long as 50 days. After habituation had reached a long-term asymptote, 600 stimulus presentations over 2-sec ISIs produced further response decrements, but these decrements recovered completely within a matter of minutes and responsiveness returned to the previously established long-term asymptote. Habituation was shown to be frequency-specific over both 24-hr and 32-day intervals. Habituation produced by stimulus presentations to awake animals transferred to the condition in which stimuli were presented to sleeping animals.
向睡眠中的大鼠呈现间隔数分钟的听觉刺激，会使脑电图（EEG）唤醒反应产生显著的习惯化。仅经过两三次刺激呈现后，唤醒反应就习惯化至渐近线水平。在间隔24或72小时的实验环节之间，几乎没有或根本没有自发恢复现象。单次刺激呈现所产生的习惯化至少持续24小时，并且在24小时的刺激间隔时间下呈现出有序的习惯化。在10次刺激呈现后32天，习惯化的保留率约为90%，并且在长达50天的时间里都呈现出一定程度的保留。在习惯化达到长期渐近线后，以2秒的刺激间隔进行600次刺激呈现会使反应进一步下降，但这些下降在几分钟内就完全恢复，反应性又回到先前确立的长期渐近线水平。在24小时和32天的时间间隔内，习惯化都表现出频率特异性。对清醒动物进行刺激呈现所产生的习惯化会转移到对睡眠动物进行刺激呈现的条件下。
