组胺对豚鼠胃平滑肌的作用。

Effect of histamine on the gastric smooth muscles of guinea pig.

作者信息

Nakazawa S, Ichikawa T, Naito Y, Tsukamoto Y

出版信息

Digestion. 1981;22(4):203-9. doi: 10.1159/000198646.

DOI:10.1159/000198646

Abstract

The responses to histamine were studied in circular smooth muscles of three different regions of the guinea pig stomach: the fundus, the antrum and the pylorus. Histamine elicited contractions in all three regions. The contractile responses to histamine were completely abolished by mepyramine (10(-3) g/l). These results showed the presence of H1 receptors, which mediate contractile response, in all regions of the stomach. In the presence of mepyramine, histamine caused marked relaxation in the preparations from the fundus contracted by acetylcholine. This relaxation was noticeably suppressed by cimetidine, indicating the existence of H2 receptors in the fundus.

摘要

在豚鼠胃的三个不同区域（胃底、胃窦和幽门）的环形平滑肌中研究了对组胺的反应。组胺在所有这三个区域均引起收缩。对组胺的收缩反应被美吡拉敏（10⁻³ g/l）完全消除。这些结果表明，胃的所有区域均存在介导收缩反应的H1受体。在存在美吡拉敏的情况下，组胺使由乙酰胆碱引起收缩的胃底标本出现明显的松弛。这种松弛被西咪替丁显著抑制，表明胃底存在H2受体。