Teshima S, Sakashita S, Kikuchi Y, Aizawa M
Gan. 1981 Aug;72(4):524-30.
Pregnant rats whose fetuses were removed on the 12th day of gestation developed tumors dysontogenetically. Out of 127 operated rats, 103 rats gave rise to tumors, which were histologically yolk sac carcinomas (52 cases), adenocarcinomas (34 cases), choriocarcinomas (8 cases) and teratomas (74 cases). Induction of malignant tumors was dependent on the male rats used for mating and the time of fetectomy. Killing of primordial germ cells by low-dose irradiation before fetectomy decreased the occurrence of tumors. These findings indicate that malignant tumors, including yolk sac carcinoma, might be of germ cell origin.
在妊娠第12天切除胎儿的怀孕大鼠会发生发育异常性肿瘤。在127只接受手术的大鼠中，103只大鼠发生了肿瘤，组织学上为卵黄囊癌（52例）、腺癌（34例）、绒毛膜癌（8例）和畸胎瘤（74例）。恶性肿瘤的诱导取决于用于交配的雄性大鼠和胎儿切除时间。在胎儿切除术前用低剂量辐射杀死原始生殖细胞可降低肿瘤的发生率。这些发现表明，包括卵黄囊癌在内的恶性肿瘤可能起源于生殖细胞。
