Suzuki E, Aoki J, Okada M
Gan. 1981 Aug;72(4):547-51.
The metabolic fate of two urinary bladder carcinogens, N-butyl-N-(4-hydroxy-butyl) nitrosamine (BBN) and N-N-dibutylnitrosamine (DBN), was studied in the guinea pig, in order to elucidate species differences of response to these N-nitrosamines in this animal species and the rat. Based on the urinary metabolites characterized after oral administration of these compounds, the metabolic pathways of BBN and DBN in the guinea pig were shown to be essentially similar to those in the rat. The principal urinary metabolite of BBN and DBN in the guinea pig, however, was not N-butyl-N-(3-carboxypropyl) nitrosamine (BCPN), as was the case in the rat, but the glucuronic acid conjugate of BBN and that of N-butyl-N-(3-hydroxybutyl) nitrosamine, respectively. The species variation in response to BBN and DBN as bladder carcinogens in these animals is discussed on the basis of the urinary excretion of BCPN.
为了阐明豚鼠和大鼠对这些N-亚硝胺反应的种属差异，研究了两种膀胱致癌物N-丁基-N-(4-羟基丁基)亚硝胺（BBN）和N-N-二丁基亚硝胺（DBN）在豚鼠体内的代谢命运。根据口服这些化合物后所鉴定出的尿液代谢产物，BBN和DBN在豚鼠体内的代谢途径显示与大鼠基本相似。然而，豚鼠体内BBN和DBN的主要尿液代谢产物并非像大鼠那样是N-丁基-N-(3-羧丙基)亚硝胺（BCPN），而是BBN的葡萄糖醛酸共轭物以及N-丁基-N-(3-羟基丁基)亚硝胺的葡萄糖醛酸共轭物。基于BCPN的尿液排泄情况，讨论了这些动物对作为膀胱致癌物的BBN和DBN反应的种属差异。
