Jarboe C H, Cook L N, Malesic I, Fleischaker J
J Clin Pharmacol. 1981 Oct;21(10):405-10. doi: 10.1002/j.1552-4604.1981.tb01741.x.
A population of 20 normal lactating females between the ages of 20 and 35 years was treated with a single 5 mg/kg intragluteal dose of dyphylline, 7-(2,3-dihydroxypropyl)theophylline. The distribution of the drug between blood and milk and its pharmacokinetics of elimination were determined. The apparent volume of distribution (Vd) of dyphylline was found to be 0.505 +/- 0.162 l./kg, the elimination rate constant (Kel) was 0.228 +/- 0.055 hr-1, the biological half-life (t1/2) was 3.21 +/- 0.76 hr, and the total body clearance (CI) was 0.109 +/- 0.036 l./kg/hr. The ratio described by dyphylline distribution between milk and serum (M/S) was 2.08 +/- 0.52. The elimination rate from milk was equivalent to that from blood.
选取了20名年龄在20至35岁之间的正常哺乳期女性，给她们单次臀内注射5毫克/千克的二羟丙茶碱（7-(2,3-二羟丙基)茶碱）。测定了该药物在血液和乳汁之间的分布及其消除的药代动力学。结果发现，二羟丙茶碱的表观分布容积（Vd）为0.505±0.162升/千克，消除速率常数（Kel）为0.228±0.055小时-1，生物半衰期（t1/2）为3.21±0.76小时，全身清除率（CI）为0.109±0.036升/千克/小时。二羟丙茶碱在乳汁与血清之间的分布比例（M/S）为2.08±0.52。乳汁中的消除速率与血液中的相当。
