Lawyer C H, Bardana E J, Rodgers R, Gerber N
J Allergy Clin Immunol. 1980 May;65(5):353-7. doi: 10.1016/0091-6749(80)90212-2.
The pharmacokinetics and urinary excretion of intravenously administered 7-(2,3-dihydroxypropyl) theophylline (dyphylline), were studied in a 37-yr-old asthmatic woman with ethylene diamine sensitivity who manifested intolerance to intravenous aminophylline on three separate occasions. In this subject, intravenously administered dyphylline was tolerated very well and was effective in the subsequent management of acute bronchospastic episodes. Dyphylline was significantly concentrated in the urine. This, coupled with its rapid clearance, suggests potential clinical application in patients with hepatic dysfunction. Though aminophylline sensitivity is rare, ethylene diamine sensitivity should be considered in untoward reactions to this drug.
对一名37岁的患有乙二胺敏感的哮喘女性进行了研究，该女性在三个不同场合对静脉注射氨茶碱不耐受，此次研究了静脉注射7-(2,3-二羟基丙基)茶碱（二羟丙茶碱）的药代动力学和尿排泄情况。在该受试者中，静脉注射二羟丙茶碱耐受性良好，对随后的急性支气管痉挛发作治疗有效。二羟丙茶碱在尿液中显著浓缩。这与其快速清除率相结合，提示其在肝功能不全患者中具有潜在的临床应用价值。虽然氨茶碱敏感性罕见，但在该药物出现不良反应时应考虑乙二胺敏感性。
